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These data also show the addition and potency of GcgR agonism as a determinate factor in the weigh-lowering and weight-normalizing efficacy of this triple receptor agonism, and the inclusion of GIPR agonism not only contributes to the weight-lowering efficacy but permits maximal GcgR engagement without a deterioration in glucose control

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Glucagon-Like Peptide 1-Based Therapies for the Treatment of Type 2 Diabetes Mellitus. Edited by David M Nathan and Katya Rubinow, UpToDate, Wolters Kluwer, 9 Nov

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